Clinical breast cancer · 2025
Activity and Efficacy of Neoadjuvant Chemotherapy in Luminal-HER2 Negative Early Breast Cancer According to HER2 Score (Low vs. Score 0): A Retrospective Study.
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Garufi Giovanna, Mastrantoni Luca, Maliziola Noemi, Di Monte Elena, Arcuri Giorgia, Frescura Valentina, Rotondi Angelachiara, Fabi Alessandra, Paris Ida, Marazzi Fabio, Franco Antonio, Franceschini Gianluca, Palazzo Antonella, Orlandi Armando, Scambia Giovanni, Tortora Giampaolo, Carbognin Luisa, Bria Emilio
Аннотация
BACKGROUND: The predictive and prognostic role of HER2 status in patients with luminal-HER2 negative early breast cancer (BC) undergoing neoadjuvant chemotherapy is unclear. A retrospective analysis evaluating the correlation between HER2 status (low vs. score 0) and pCR/IDFS was conducted.
METHODS: Patients with BC undergoing neoadjuvant chemotherapy and surgery were included. HER2 low BC was defined as IHC 1+ or 2+ with negative FISH. Logistic regression model and Cox proportional hazard model were adopted to investigate the independent role of HER2 status and outcomes of interest (pCR, CPS-EG and IDFS).
RESULTS: About 566 patients were included: 60% were HER2 low and 40% were HER2 0. pCR was achieved in 13.2% of HER2 low versus 17.7% of HER2 0 (P = .15). There was no correlation between baseline HER2 status and CPS-EG score (P = .18). A trend toward improved IDFS for HER2 low BC was observed (P = .07). The relapse rate of the HER2 0 cohort peaked at 12 months after surgery, similar to the HER2 low cohort, which showed an additional peak at 36 months after surgery.
CONCLUSIONS: Among Luminal-HER2 negative early BCs, our results do not support a clear predictive and prognostic effect of HER2 status, although a trend of worse pCR and better survival for HER2 low BCs cannot be ruled out.
METHODS: Patients with BC undergoing neoadjuvant chemotherapy and surgery were included. HER2 low BC was defined as IHC 1+ or 2+ with negative FISH. Logistic regression model and Cox proportional hazard model were adopted to investigate the independent role of HER2 status and outcomes of interest (pCR, CPS-EG and IDFS).
RESULTS: About 566 patients were included: 60% were HER2 low and 40% were HER2 0. pCR was achieved in 13.2% of HER2 low versus 17.7% of HER2 0 (P = .15). There was no correlation between baseline HER2 status and CPS-EG score (P = .18). A trend toward improved IDFS for HER2 low BC was observed (P = .07). The relapse rate of the HER2 0 cohort peaked at 12 months after surgery, similar to the HER2 low cohort, which showed an additional peak at 36 months after surgery.
CONCLUSIONS: Among Luminal-HER2 negative early BCs, our results do not support a clear predictive and prognostic effect of HER2 status, although a trend of worse pCR and better survival for HER2 low BCs cannot be ruled out.