[Isoniazid therapy in severe cerebellar, postural and kinetic tremor].

In the routine analysis of patients with tremors, we have the routine analysis of patients with tremors, we have encountered three patients with severe cerebellar postural & kinetic tremors. Surface EMG study revealed alternating activity in antagonistic muscles with low frequency (3-5 cps) and wide duration (over 125msecs). They were different to typical essential tremor & parkinson's tremor in the clinical manifestation and tremogram. The tremor did not respond to high dose of propranolol (120-160mg/day), but responded to high dose of isoniazid (800-1200mg/day). Patients were evaluated before & after INH therapy with videotaping, surface EMG quantitative recording. One patient had transient side effects (abnormal liver function) in the beginning of treatment possibly because he was a "slow acetylator". The possible mechanism of effort of INH was discussed.