Transcriptomic and epigenomic biomarkers of antidepressant response.

BACKGROUND

Antidepressant treatment is associated with a high rate of poor response, and thus, biomarker development is warranted.

METHODS

We aimed to synthesize studies investigating gene expression, small RNAs, and epigenomic biomarkers of antidepressant response. We conducted a narrative review of the literature.

RESULTS

Firstly, we detailed the challenges involved, in terms of biological tissues, relevant study time frames, and mandatory statistical tools. Secondly we synthesized results obtained in gene expression studies, focusing mainly on genome-wide studies, particularly small non-coding RNA, including micro-RNA and other small RNA species. In addition, we reviewed the potential biomarkers of antidepressant response arising from studies investigating DNA methylation variation and histone modifications.

LIMITATIONS: We did not conduct a meta-analysis due to the heterogeneity of the study.

CONCLUSION

Although promising, the field of gene expression and epigenomic biomarkers of antidepressant response is still in its infancy, and needs further development to define useful biomarkers in clinical practice.