Effect of two trematodicidal drugs on the morphology and tegumentary ultrastructure of Schistosoma mansoni.

A study of the effects on the tegument of S. mansoni adult worm following in vivo praziquantel and triclabendazole treatment was performed. The topographic changes observed in treated adults were in the form of blebs and vesicles covering the surface of the worm with disappearance of spines and disorganization of the tegument. The ventral sucker was completely retracted in praziquantel treated worms however, in triclabendazole the oral sucker was mainly affected. The difference in tegumental changes between the two drugs may be due to the difference in their mode of action.