Journal of Parkinson's disease · 2017
Statins and Cognition in Parkinson's Disease.
СтатьяПоддержка NIH: внешняя программаНазвание и аннотация: Перевод пока не подготовлен
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Deck Benjamin L, Rick Jacqueline, Xie Sharon X, Chen-Plotkin Alice, Duda John E, Morley James F, Chahine Lana M, Dahodwala Nabila, Trojanowski John Q, Weintraub Daniel
Аннотация
BACKGROUND: The relationship between statins and cognition in Parkinson's disease (PD) is poorly understood.
OBJECTIVES: Analyses were performed to determine associations between statin use and cross-sectional and longitudinal cognitive performance in PD.
METHODS: Neuropsychological tests, medication logs, and ratings of functional abilities were collected from 313 PD participants longitudinally.
RESULTS: At baseline, statin users (SU; N = 129) were older, more likely male, and had shorter PD duration than non-statin users (NSU; N = 184). In Cross-sectional analysis, SU performed better on global cognition, Trails B, semantic fluency, and phonemic fluency tasks. Rate of long-term global cognitive (Dementia Rating Scale-2 and MoCA) decline was significantly less in SU.
OBJECTIVES: Analyses were performed to determine associations between statin use and cross-sectional and longitudinal cognitive performance in PD.
METHODS: Neuropsychological tests, medication logs, and ratings of functional abilities were collected from 313 PD participants longitudinally.
RESULTS: At baseline, statin users (SU; N = 129) were older, more likely male, and had shorter PD duration than non-statin users (NSU; N = 184). In Cross-sectional analysis, SU performed better on global cognition, Trails B, semantic fluency, and phonemic fluency tasks. Rate of long-term global cognitive (Dementia Rating Scale-2 and MoCA) decline was significantly less in SU.