Risk Factors for Hyperamylasemia After Laparoscopic Common Bile Duct Exploration with Primary Closure: A Retrospective Study.

BACKGROUND

This study aims to investigate the incidence of hyperamylasemia after LCBDE with primary closure and to identify the associated risk factors.

METHODS

A retrospective analysis of 436 patients categorized by serum amylase levels was performed. Univariate and multivariate logistic regression analyses were performed to identify risk factors, and clinical interventions were compared between patients with and without postoperative hyperamylasemia.

RESULTS

Hyperamylasemia occurred in 53 patients (12.2%), with 10 cases exceeding three times the upper limit of normal and 4 cases (0.9%) diagnosed with pancreatitis. Independent risk factors included longer surgical duration (OR = 1.008, p = 0.035), postoperative abdominal drainage (OR = 2.216, p = 0.045), and differences in neutrophil counts (OR = 1.242, p = 0.038). Although hyperamylasemia showed no significant association with short-term overall complications (p = 1.000) or individual complications (p > 0.05), it was linked to longer postoperative (p = 0.022) and total hospital stays (p = 0.032), higher hospitalization costs (p = 0.036), and greater postoperative use of antibiotics (p = 0.013), antispasmodics, and analgesics (p = 0.037).

CONCLUSION

Hyperamylasemia after LCBDE is linked to specific risk factors, but its clinical significance remains limited. Accurate recognition is crucial to avoid unnecessary interventions.