Nature reviews. Drug discovery · 2010
Biomarkers for Alzheimer's disease: academic, industry and regulatory perspectives.
СтатьяПоддержка исследования: вне правительства СШАОбзорНазвание и аннотация: Перевод пока не подготовлен
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Hampel Harald, Frank Richard, Broich Karl, Teipel Stefan J, Katz Russell G, Hardy John, Herholz Karl, Bokde Arun L W, Jessen Frank, Hoessler Yvonne C, Sanhai Wendy R, Zetterberg Henrik, Woodcock Janet, Blennow Kaj
Аннотация
Advances in therapeutic strategies for Alzheimer's disease that lead to even small delays in onset and progression of the condition would significantly reduce the global burden of the disease. To effectively test compounds for Alzheimer's disease and bring therapy to individuals as early as possible there is an urgent need for collaboration between academic institutions, industry and regulatory organizations for the establishment of standards and networks for the identification and qualification of biological marker candidates. Biomarkers are needed to monitor drug safety, to identify individuals who are most likely to respond to specific treatments, to stratify presymptomatic patients and to quantify the benefits of treatments. Biomarkers that achieve these characteristics should enable objective business decisions in portfolio management and facilitate regulatory approval of new therapies.