Revue neurologique · 2025
Long-lasting improvement of memory after targeted cognitive remediation in temporal epilepsy: A randomized control study.
СтатьяРандомизированное исследованиеМногоцентровое исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Forthoffer N, Maillard L, Thiriaux A, Lemesle Martin M, Vignal J P, Brissart H
Аннотация
BACKGROUND: Memory deficits are a major burden in temporal lobe epilepsy (TLE), contributing to the impaired quality of life of patients. Short- and long-term efficacy of memory remediation in TLE is still debated. The aim of our study was to assess the short- and long-term efficacy of a cognitive remediation program, COMETE (COgnitive Rehabilitation of MEmory in Temporal Epilepsy), targeting specifically episodic memory in patients with TLE.
METHODS: In this prospective randomized single-blinded trial, patients from different French epilepsy centers were randomly assigned in a 2:4 ratio, via a computer-generated code, to receive remediation intervention or no intervention between neuropsychological assessments. Neuropsychologists assessing the cognitive performance at baseline, at immediate follow-up (3months after baseline) and in long-term follow-up (10 to 12months after baseline) were blinded to the intervention allocation.
RESULTS: Sixty out of 66 included patients were randomized. Patients in the Remediation group significantly improved their performances in the subtests addressed by the program (verbal and non-verbal memory; P<0.001 at 3months and P<0.001 at 10/12months) while patients in the Control group did not. In verbal memory, 56% of the patients in the Remediation group normalized their performance in verbal memory learning score while 7% of the patients in the Control group did.
CONCLUSIONS: Cognitive remediation targeting memory is efficient at short and long term in temporal lobe epilepsy patients.
METHODS: In this prospective randomized single-blinded trial, patients from different French epilepsy centers were randomly assigned in a 2:4 ratio, via a computer-generated code, to receive remediation intervention or no intervention between neuropsychological assessments. Neuropsychologists assessing the cognitive performance at baseline, at immediate follow-up (3months after baseline) and in long-term follow-up (10 to 12months after baseline) were blinded to the intervention allocation.
RESULTS: Sixty out of 66 included patients were randomized. Patients in the Remediation group significantly improved their performances in the subtests addressed by the program (verbal and non-verbal memory; P<0.001 at 3months and P<0.001 at 10/12months) while patients in the Control group did not. In verbal memory, 56% of the patients in the Remediation group normalized their performance in verbal memory learning score while 7% of the patients in the Control group did.
CONCLUSIONS: Cognitive remediation targeting memory is efficient at short and long term in temporal lobe epilepsy patients.