Antimicrobial Resistance of Environmental V. cholerae Non-O1/O139 Isolates: Systematic Review and Meta-analysis.

BACKGROUND

The understanding of the antibiotic resistance status of environmental nonO1/nonO139 V. cholerae (NOVC) in relation to other illnesses, which can vary in severity from mild to life-threatening, is limited. However, it is important to note that NOVC-related infections are increasing and serve as a significant illustration of emerging human diseases associated with climate change. The primary objective of the present study was to assess the rates of resistance observed in environmental NOVC isolates across various years, and regions, and their resistance rates.

METHODS

We performed a systematic search of Scopus, PubMed, Web of Science, and EMBASE databases (until May 2024) following PRISMA guidelines. All statistical analyses were carried out using the statistical package R.

RESULTS

Our analysis included a total of 34 studies. According to the meta-regression, chloramphenicol, rifampicin, ciprofloxacin, nalidixic acid, cotrimoxazole, kanamycin, trimethoprim, amoxicillin/clavulanic acid, and tetracycline resistance rate increased over time. The lowest resistance rates were observed in Austria (amoxicillin; 0.6%), the United States (kanamycin; 0.1% and tetracycline; 0.1%), Morocco (polymyxin B; 12%), and Spain (trimethoprim; 0.3%). Conversely, the highest resistance rates were found in Spain (amoxicillin; 61%), Indonesia (kanamycin and tetracycline; 94.9%), India (polymyxin B; 97.8%), and Morocco (trimethoprim; 48.9%).

CONCLUSION

The meta-analysis showed significant variability in antibiotic resistance patterns among environmental NOVC isolates across time and regions, emphasizing the need for targeted, time-specific, and country-specific approaches to address antibiotic resistance globally.