Internal medicine (Tokyo, Japan) · 2010
Long-term suppressive effect of octreotide on progression of metastatic gastrinoma with multiple endocrine neoplasia type 1: seven-year follow up.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Yamaguchi Megu, Yamada Yuya, Hosokawa Yoshiya, Iwamoto Ryuya, Tamba Sachiko, Ihara Arisa, Yamamoto Koji, Hoshida Yoshihiko, Matsuzawa Yuji
Аннотация
A 30-year-old woman had a history of prolactinoma and primary hyperparathyroidism. She was diagnosed as having multiple endocrine neoplasia type 1 with gastrinoma and liver metastases. Octreotide therapy was started and the serum gastrin level decreased immediately. Octreotide continued to suppress gastrin secretion over the next 7 years. The Ki67/MIB1 proliferation index of this tumor was only 0.5 % and somatostatin receptor (SSTR) 2 expression was very strong in both 2002 and 2009. This case suggests the importance of investigating the Ki67/MIB1 index and SSTR expression in patients with metastatic gastrinoma.