Inflammatory bowel diseases in Tamil Nadu: A survey of demographics, clinical profile, and practices.
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Yewale Rohan V, Natarajan Kartik, Ubal Dhus Jeyaraj, Parameswaran Sarojini Ashok, Ramaswamy Palaniswamy Kallipatti, Babu Vinish Doraisamy, Somasundaram Aravindh, Ramakrishnan Arulraj, Karmegam Sibithooran, Arun Ramaswamy Saraswathy, Manmohan Ujjani Shankaraiah, Mahadevan Balakrishnan, Harri Prasad Baskkaran, Chandrasekar Toguluva Seshadri, Gokul Bollu Janakan, Dutta Amit, Joseph Anjilivelil Joseph, Venkatraman Jayanthi, Ganesh Panchapakesan, Shanmuganathan Subramanyam, Alagammai Palaniappan L, Ramasubramanian Ramalingam, Venkatakrishnan Leelakrishnan, Ganesan Ramamoorthi, Chandrasekaran Arun Arunachalam, Srinivas Sankaranarayanan, Kannan Mariappan, Revathy M Shanmugam, Sathiyasekaran Malathi, Sarangapani Arulprakash, Rajesh Natrajan, Arulselvan Velusamy, Aravind Arumugam, Premkumar Karunakaran, Kavitha Sampath, Varadarajulu Hema Vijayalakshmi, Manimaran Murugesan, Basumani Pandurangan, Murali Ananthavadivelu, Ramakrishna Balakrishnan Siddartha
Аннотация
METHODS: TNISG members from 32 institutions completed an online cross-sectional questionnaire on IBD patients from March 2020 to January 2021.
RESULTS: Of 1295 adult IBD patients, 654 had Crohn's disease (CD), 499 ulcerative colitis (UC), and 42 IBD-unclassified (IBD-U). CD and UC showed a unimodal age distribution. A total of 55% were graduates or postgraduates. A positive family history was noted in 30, other risk factors were uncommon. In CD, the pattern of involvement was ileocolonic (42.8%), ileal (34.7%), colonic (18.9%), and upper gastrointestinal (3.5%); while in UC, disease was characterized as extensive (44.9%), left-sided (41.7%), or proctitis (13.4%). Perineal disease, perianal fistulae, and bowel obstruction were noted in 4.3, 14.0, and 23.5%, respectively, of CD. The most widely used drugs were mesalamine, azathioprine, and corticosteroids. Surgery was undertaken in 141 patients with CD and 23 patients with UC. Of the 138 patients with pediatric IBD (≤16 years), 23 were characterized as very early onset IBD (VEO-IBD), 27 as early-onset, and 88 as adolescent IBD. VEO-IBD were more likely to have a positive family history of IBD and were more likely to have perineal disease and to have the IBD-U phenotype. Among pediatric IBD patients, corticosteroids, mesalamine, and azathioprine were the most commonly used medications, while 25 pediatric patients received biologics.
CONCLUSION: This study provides important information on demography, clinical profile, and treatment practices of IBD in India.