Association of ultra-processed food intake with risk of inflammatory bowel disease: prospective cohort study.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Narula Neeraj, Wong Emily C L, Dehghan Mahshid, Mente Andrew, Rangarajan Sumathy, Lanas Fernando, Lopez-Jaramillo Patricio, Rohatgi Priyanka, Lakshmi P V M, Varma Ravi Prasad, Orlandini Andres, Avezum Alvaro, Wielgosz Andreas, Poirier Paul, Almadi Majid A, Altuntas Yuksel, Ng Kien Keat, Chifamba Jephat, Yeates Karen, Puoane Thandi, Khatib Rasha, Yusuf Rita, Boström Kristina Bengtsson, Zatonska Katarzyna, Iqbal Romaina, Weida Liu, Yibing Zhu, Sidong Li, Dans Antonio, Yusufali Afzalhussein, Mohammadifard Noushin, Marshall John K, Moayyedi Paul, Reinisch Walter, Yusuf Salim
Аннотация
DESIGN: Prospective cohort study.
SETTING: 21 low, middle, and high income countries across seven geographical regions (Europe and North America, South America, Africa, Middle East, south Asia, South East Asia, and China).
PARTICIPANTS: 116 087 adults aged 35-70 years with at least one cycle of follow-up and complete baseline food frequency questionnaire (FFQ) data (country specific validated FFQs were used to document baseline dietary intake). Participants were followed prospectively at least every three years.
MAIN OUTCOME MEASURES: The main outcome was development of IBD, including Crohn's disease or ulcerative colitis. Associations between ultra-processed food intake and risk of IBD were assessed using Cox proportional hazard multivariable models. Results are presented as hazard ratios with 95% confidence intervals.
RESULTS: Participants were enrolled in the study between 2003 and 2016. During the median follow-up of 9.7 years (interquartile range 8.9-11.2 years), 467 participants developed incident IBD (90 with Crohn's disease and 377 with ulcerative colitis). After adjustment for potential confounding factors, higher intake of ultra-processed food was associated with a higher risk of incident IBD (hazard ratio 1.82, 95% confidence interval 1.22 to 2.72 for ≥5 servings/day and 1.67, 1.18 to 2.37 for 1-4 servings/day compared with <1 serving/day, P=0.006 for trend). Different subgroups of ultra-processed food, including soft drinks, refined sweetened foods, salty snacks, and processed meat, each were associated with higher hazard ratios for IBD. Results were consistent for Crohn's disease and ulcerative colitis with low heterogeneity. Intakes of white meat, red meat, dairy, starch, and fruit, vegetables, and legumes were not associated with incident IBD.
CONCLUSIONS: Higher intake of ultra-processed food was positively associated with risk of IBD. Further studies are needed to identify the contributory factors within ultra-processed foods.
STUDY REGISTRATION: ClinicalTrials.gov NCT03225586.