[Comparative evaluation of the dynamics of physico-chemically different serum O- and K-antibodies in typhoid and chronic typhoid carriers].

The character of immune response to different S. typhi antigens in typhoid fever and chronic typhoid carriership was studied. The comparative evaluation of the functional activity of different classes of immunoglobulins was carried out by means of the indirect immunofluorescent method. 34 typhoid patients and 34 chronic carriers were examined. The speed of change-over from the production of IgM to that of IgG was found to be linked-with the nature of antigenic stimulation. In the dynamics of typhoid infection the changeover from the production of IgM to that of IgG specific to S. typhi O-antigen was observed. At a later period of typhoid fever the spectrum of O-antibodies was similar in their physico-chemical characteristics to that in chronic carriers. K-antibodies in chronic carriers were represented by highly active IgG.