Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2005
Prolonged (more than ten hours) neuromuscular blockade after cardiac surgery: report of two cases.
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Olivieri Lori, Plourde Gilles
Аннотация
PURPOSE: We examine two cases of prolonged neuromuscular blockade (NMB) after cardiac surgery. To the best of our knowledge, these are the first reported cases of complete paralysis lasting more than ten hours after surgery.
CLINICAL FEATURES: We attribute the extended durations of NMB (more than ten hours) to high doses of NMB drugs in combination with magnesium sulphate and moderate renal failure. Advanced age, hepatic disease, aminoglycoside exposure, hypocalcemia, and possible interaction between rocuronium and pancuronium may have played minor roles.
CONCLUSION: We should avoid administering large doses of NMB agents, even in the context of planned postoperative ventilation. If NMB is not monitored intraoperatively in patients who are at risk of prolonged NMB, then train-of-four response should be measured in the intensive care unit. Adequate sedation should be provided until proper recovery of neuromuscular function is documented.
CLINICAL FEATURES: We attribute the extended durations of NMB (more than ten hours) to high doses of NMB drugs in combination with magnesium sulphate and moderate renal failure. Advanced age, hepatic disease, aminoglycoside exposure, hypocalcemia, and possible interaction between rocuronium and pancuronium may have played minor roles.
CONCLUSION: We should avoid administering large doses of NMB agents, even in the context of planned postoperative ventilation. If NMB is not monitored intraoperatively in patients who are at risk of prolonged NMB, then train-of-four response should be measured in the intensive care unit. Adequate sedation should be provided until proper recovery of neuromuscular function is documented.
Предметные рубрики MeSH
Acute Kidney InjuryAgedAminoglycosidesAndrostanolsAnesthesia Recovery PeriodAortaAortic ValveCardiac Surgical ProceduresCoronary Artery BypassDrug InteractionsFemaleHeart Valve Prosthesis ImplantationHumansHypocalcemiaLiver DiseasesMagnesium SulfateMitral ValveNeuromuscular BlockadeNeuromuscular Nondepolarizing AgentsPancuroniumParalysisRocuronium