DNA Origami Nanotechnology in Aging-Related Degenerative Diseases: Current Advances and Future Directions.

Aging-related degenerative diseases, particularly neurodegenerative, musculoskeletal, and cardiovascular disorders, represent a major global health challenge. Characterized by progressive and irreversible cellular and tissue deterioration, these conditions contribute substantially to disability, loss of function, and mortality in older populations. Despite advances in symptom management, early diagnosis and effective therapies remain limited, largely due to complex and multifactorial pathogenesis. DNA origami, an emerging nanotechnology, offers unique advantages such as nanoscale precision, structural programmability, biodegradability, and low toxicity, making it a promising platform for biomedical applications. Recent progress has highlighted its utility in biosensing, bioimaging, molecular detection, targeted drug delivery, immune modulation, and receptor recognition in models of aging-related degenerative diseases. Here, we summarize current advances in DNA origami-based biomedical applications for aging-related degenerative disorders and discuss key challenges including in vivo stability, large-scale production, and translational feasibility. Collectively, DNA origami provides a convergent and versatile strategy with significant potential to improve precision diagnosis and treatment of aging-related degenerative diseases, opening avenues for future clinical applications in nanomedicine.