Journal of clinical and diagnostic research : JCDR · 2016
Effect of Silybin on Lipid Profile in Hypercholesterolaemic Rats.
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Gobalakrishnan Senthil, Asirvatham Sylvia Santhakumari, Janarthanam Venkatraman
Аннотация
INTRODUCTION: Hyperlipidemia is a major cause of atherosclerosis and atherosclerosis associated conditions, such as Coronary Heart Disease (CHD), ischaemic cerebrovascular disease and peripheral vascular disease. Though there are hypolipidemic drugs available, the search for a more efficacious hypo lipidemic agent was always going on.
AIM: To study the effect of Silybin on lipid profile in Hypercholesterolaemic rats.
MATERIALS AND METHODS: After grant of permission from animal ethics committee, the animals were divided into four groups of eight each (normal control, Experimental control with High cholesterol diet, High cholesterol diet + Silybin 300mg, High cholesterol diet + Silybin 600mg). At the end of 60 days the animals in all the groups were subjected to overnight fasting followed by plasma and liver biochemical analyses.
STATISTICAL ANALYSIS: The data were analysed by ANNOVA followed by Duncan's multi range test and the value of p≤0.05 was used as the criterion for statistical significance.
RESULTS: The rats fed on high cholesterol diet showed significant increase in serum total cholesterol, Triglycerides, LDL-C and VLDL-C. Treatment with Silybin significantly decreased serum total cholesterol (24%), Triglycerides (21%), LDL-C (24%) in a dose dependent manner. Rats treated with Silybin (300 and 600 mg/kg) showed significant increase in hepatic HDL -C and decrease in other lipid profiles.
CONCLUSION: Treatment with Silybin significantly decreased both serum and hepatic total cholesterol, triglycerides, VLDL-C, LDL-C and increased HDL-C at both doses.
AIM: To study the effect of Silybin on lipid profile in Hypercholesterolaemic rats.
MATERIALS AND METHODS: After grant of permission from animal ethics committee, the animals were divided into four groups of eight each (normal control, Experimental control with High cholesterol diet, High cholesterol diet + Silybin 300mg, High cholesterol diet + Silybin 600mg). At the end of 60 days the animals in all the groups were subjected to overnight fasting followed by plasma and liver biochemical analyses.
STATISTICAL ANALYSIS: The data were analysed by ANNOVA followed by Duncan's multi range test and the value of p≤0.05 was used as the criterion for statistical significance.
RESULTS: The rats fed on high cholesterol diet showed significant increase in serum total cholesterol, Triglycerides, LDL-C and VLDL-C. Treatment with Silybin significantly decreased serum total cholesterol (24%), Triglycerides (21%), LDL-C (24%) in a dose dependent manner. Rats treated with Silybin (300 and 600 mg/kg) showed significant increase in hepatic HDL -C and decrease in other lipid profiles.
CONCLUSION: Treatment with Silybin significantly decreased both serum and hepatic total cholesterol, triglycerides, VLDL-C, LDL-C and increased HDL-C at both doses.