MedElevator Войти в исследования
← Поиск публикаций

DOI 10.2217/bmm-2019-0384

Медицинская библиотека · Biomarkers in medicine · 2020

Associations between TAB2 gene polymorphisms and dilated cardiomyopathy in a Chinese population.

Shen Can, Zhong Yue, Huang Xingming, Wang Yanyun, Peng Ying, Li Kai, Zhou Bin, Zhang Lin, Rao Li

СтатьяПоддержка исследования: вне правительства СШАПеревод пока не подготовлен

Аннотация

Aim: The present study aimed to investigate the role of TAB2 gene polymorphisms in dilated cardiomyopathy (DCM) susceptibility and prognosis in a Chinese population. Materials & methods: A total of 343 DCM patients and 451 controls were enrolled and had their blood genotyped. Survival analysis was evaluated with Kaplan-Meier curves and Cox regression analysis.

Results

G carriers (AG/GG) and AG genotype of rs237028 had a higher DCM susceptibility as well as a worse DCM prognosis. Additionally, C carriers (CT/CC) of rs652921 and G carriers (TG/GG) of rs521845 had a higher DCM risk and CC homozygote of rs652921 had a worse DCM prognosis. These associations were still significant after adjustment for the Bonferroni correction.

Conclusion

TAB2 gene polymorphisms were associated with DCM susceptibility and prognosis in the Chinese population.

Для цитирования: Shen Can, Zhong Yue, Huang Xingming, Wang Yanyun, Peng Ying, Li Kai, Zhou Bin, Zhang Lin, Rao Li. Associations between TAB2 gene polymorphisms and dilated cardiomyopathy in a Chinese population.. Biomarkers in medicine. 2020. DOI: 10.2217/bmm-2019-0384.

Предметные рубрики MeSH

Adaptor Proteins, Signal TransducingAdultCardiomyopathy, DilatedCase-Control StudiesChinaFemaleGenetic Predisposition to DiseaseHumansKaplan-Meier EstimateLinkage DisequilibriumMaleMiddle AgedPolymorphism, Single Nucleotide
Подготовка и перевод публикации
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…

История · было → стало

Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.

Тип публикации указан по данным источника. Уровень доказательности автоматически не присваивается.