Viruses · 2021
SARS-CoV-2 Reinfection in a Healthcare Worker Despite the Presence of Detectable Neutralizing Antibodies.
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Brehm Thomas Theo, Pfefferle Susanne, von Possel Ronald, Kobbe Robin, Nörz Dominik, Schmiedel Stefan, Grundhoff Adam, Olearo Flaminia, Emmerich Petra, Robitaille Alexis, Günther Thomas, Braun Platon, Andersen Gabriele, Knobloch Johannes K, Addo Marylyn M, Lohse Ansgar W, Aepfelbacher Martin, Fischer Nicole, Schulze Zur Wiesch Julian, Lütgehetmann Marc
Аннотация
So far, only a few reports about reinfections with SARS-CoV-2 have been published, and they often lack detailed immunological and virological data. We report about a SARS-CoV-2 reinfection with a genetically distinct SARS-CoV-2 variant in an immunocompetent female healthcare worker that has led to a mild disease course. No obvious viral escape mutations were observed in the second virus variant. The infectious virus was shed from the patient during the second infection episode despite the presence of neutralizing antibodies in her blood. Our data indicate that a moderate immune response after the first infection, but not a viral escape, did allow for reinfection and live virus shedding.