International journal of cardiology · 2010
Increased serum neopterin in patients with nonrheumatic aortic valve stenosis.
Сравнительное исследованиеПисьмо в редакциюПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Naito Yoshiro, Tsujino Takeshi, Akahori Hirokuni, Matsumoto Mika, Ohyanagi Mitsumasa, Mitsuno Masataka, Miyamoto Yuji, Masuyama Tohru
Аннотация
BACKGROUND: Inflammation and immunity play an intrinsic role in the pathogenesis of NR-AS. Neopterin is mainly produced by activated macrophages.
METHODS: We examined serum neopterin levels in 51 patients undergoing valve replacement surgery [37 NR-AS and 14 aortic regurgitation (AR)].
RESULTS: Serum neopterin levels were significantly higher in patients with NR-AS than in those with AR and age matched controls, whereas serum high-sensitivity C-reactive protein (hs-CRP) levels did not differ among three groups. Moreover, serum neopterin levels were not different between NR-AS patients with and without coronary artery disease.
CONCLUSIONS: Serum neopterin levels appear to be a useful maker in patients with NR-AS.
METHODS: We examined serum neopterin levels in 51 patients undergoing valve replacement surgery [37 NR-AS and 14 aortic regurgitation (AR)].
RESULTS: Serum neopterin levels were significantly higher in patients with NR-AS than in those with AR and age matched controls, whereas serum high-sensitivity C-reactive protein (hs-CRP) levels did not differ among three groups. Moreover, serum neopterin levels were not different between NR-AS patients with and without coronary artery disease.
CONCLUSIONS: Serum neopterin levels appear to be a useful maker in patients with NR-AS.