The British journal of radiology · 2011
Voxel-based diffusion tensor imaging detects pyramidal tract degeneration in primary lateral sclerosis.
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Tzarouchi L C, Kyritsis A P, Giannopoulos S, Astrakas L G, Diakou M, Argyropoulou M I
Аннотация
OBJECTIVE: Primary lateral sclerosis (PLS) is a progressive degenerative disorder affecting upper motor neurons and requires a clinical diagnosis. Diffusion tensor imaging (DTI) is a quantitative method for assessing white matter fibre integrity. The purpose of the study was to evaluate the involvement of upper motor neurons by using DTI in PLS.
METHODS: A patient with PLS was compared with eight age-matched controls. Differences in fractional anisotropy (FA) index were assessed using DTI on a voxel-by-voxel basis.
RESULTS: Decreased FA was observed in the proximal part of the pyramidal tract bilaterally, which indicated degeneration of the pyramidal cells.
CONCLUSION: Voxel-based DTI could be used as an objective marker for detecting upper motor neuron degeneration in PLS.
METHODS: A patient with PLS was compared with eight age-matched controls. Differences in fractional anisotropy (FA) index were assessed using DTI on a voxel-by-voxel basis.
RESULTS: Decreased FA was observed in the proximal part of the pyramidal tract bilaterally, which indicated degeneration of the pyramidal cells.
CONCLUSION: Voxel-based DTI could be used as an objective marker for detecting upper motor neuron degeneration in PLS.