Thrombophilia and Immune-Related Genetic Markers in Long COVID.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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da Silva Rosilene, de Sarges Kevin Matheus Lima, Cantanhede Marcos Henrique Damasceno, da Costa Flávia Póvoa, Dos Santos Erika Ferreira, Rodrigues Fabíola Brasil Barbosa, de Nazaré do Socorro de Almeida Viana Maria, de Meira Leite Mauro, da Silva Andréa Luciana Soares, de Brito Mioni Thieli Magalhães, da Silva Torres Maria Karoliny, Queiroz Maria Alice Freitas, Vallinoto Izaura Maria Vieira Cayres, Henriques Daniele Freitas, Dos Santos Carla Pinheiro, Viana Giselle Maria Rachid, Quaresma Juarez Antônio Simões, Falcão Luiz Fábio Magno, Vallinoto Antonio Carlos Rosário, Dos Santos Eduardo José Melo
Аннотация
Aiming to evaluate the role of ten functional polymorphisms in long COVID, involved in major inflammatory, immune response and thrombophilia pathways, a cross-sectional sample composed of 199 long COVID (LC) patients and a cohort composed of 79 COVID-19 patients whose follow-up by over six months did not reveal any evidence of long COVID (NLC) were investigated to detect genetic susceptibility to long COVID. Ten functional polymorphisms located in thrombophilia-related and immune response genes were genotyped by real time PCR. In terms of clinical outcomes, LC patients presented higher prevalence of heart disease as preexistent comorbidity. In general, the proportions of symptoms in acute phase of the disease were higher among LC patients. The genotype AA of the interferon gamma (IFNG) gene was observed in higher frequency among LC patients (60%; p = 0.033). Moreover, the genotype CC of the methylenetetrahydrofolate reductase (MTHFR) gene was also more frequent among LC patients (49%; p = 0.045). Additionally, the frequencies of LC symptoms were higher among carriers of IFNG genotypes AA than among non-AA genotypes (Z = 5.08; p < 0.0001). Two polymorphisms were associated with LC in both inflammatory and thrombophilia pathways, thus reinforcing their role in LC. The higher frequencies of acute phase symptoms among LC and higher frequency of underlying comorbidities might suggest that acute disease severity and the triggering of preexisting condition may play a role in LC development.