[Invasive mycoses in France: what are the trends?].

The most frequent invasive mycoses in France are candidemia, Pneumocystis jirovecii pneumonia, and invasive aspergillosis. They occur primarily in immunocompromised patients. The risk of Pneumocystis pneumonia and cryptococcosis has notably decreased for people living with HIV through the past two decades. Patients with diabetes or an autoimmune disease represent an increasing proportion of these cases. Mortality of invasive mycoses is still high, particularly in cases of candidemia and invasive aspergillosis. Azole-resistant Aspergillus spp. isolates remain rare in France and the proportion of resistant strains in cases of invasive candidiasis is stable. The emergence of Candida auris, which is associated with outbreaks in healthcare facilities, is closely monitored. Except for candidemia, investigation of predisposing genetic conditions should mainly be conducted when invasive mycosis occurs in patients without any clear risk factor.