Immunochemical comparison of cell-wall antigens of various viridans streptococci, including strain 2A2+3 hot from recurrent oral aphthous ulceration in man.

Several studies suggest that patients with recurrent aphthous ulceration show cell-mediated and humoral immunity to antigens of Streptococcus sanguis, particularly strain 2A2+3 HOT which is said to be antigenically similar or identical to Strep. sanguis strain ATCC 10556. However, physiological classification as well as analysis of the immunologically dominant cell-wall antigens by immunoelectrophoresis and indirect immunofluorescence showed that the strain is actually a strain of Streptococcus mitis and is antigenically more like ATCC 10557 than ATCC 10556. The findings illustrate the antigenic heterogeneity of the Strep. sanguis and Strep. mitis taxons, and demonstrate the need for antigenic analysis of viridans streptococcal strains used in immunological studies of the aetiology of disease and in antiserum production. Commercial streptococcal group and antisera were also tested.