Innovative synergy of bone xenograft and quercetin in the alveolar bone socket: Histological and immunohistochemical assessment of healing.

BACKGROUND

After an extraction, the alveolar bone may undergo shrinkage, making it more challenging to place dental implants and compromising the appearance of prosthetic rehabilitation. Studies show that alveolar bone resorption could reach 50% of the original ridge width within the first six months after extraction. Xenografts have shown promising outcomes because they are biocompatible, resemble human bone, and facilitate the growth of new bone. Xenografts, on the other hand, are mostly used as a scaffold for new bone to grow on and don't cause bone growth on their own. Because of this, their integration and remodeling often take a long time and don't always happen completely. This has led researchers to look into other biological agents that can speed up healing and bone growth. Quercetin has been shown to be bioactive, meaning it can fight inflammation and act as an antioxidant. Using a bone xenograft or another suitable carrier or scaffold with quercetin may make it more stable and concentrated at the defect site. This combination may provide the osteoconductive framework necessary for new bone deposition, as well as the osteopromotive qualities of quercetin, to accelerate the cellular and molecular processes related to healing.

METHODS

This study involved 64 healthy Wistar rats. The animals were randomly divided into four groups. The animals were euthanized seven to twenty-one days after extraction.Combining quercetin with a xenogenic bone graft greatly speeds up the repair of the alveolar socket. The combination encourages the production of new bone early on.

CONCLUSION

The combination of quercetin and bone xenograft significantly improved the repair of alveolar bone sockets in Wistar rats.