Anticancer research · 2018
Whole-brain Radiation Therapy for Breast Cancer Patients with Dural Metastasis Without Concomitant Brain Metastasis and Leptomeningeal Metastasis.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Sakaguchi Masakuni, Maebayashi Toshiya, Aizawa Takuya, Ishibashi Naoya
Аннотация
AIM: To evaluate outcomes of breast cancer patients with confirmed dural metastasis (DM) alone who received whole-brain radiation therapy (WBRT).
PATIENTS AND METHODS: The medical records of thirty-three breast cancer patients who received WBRT to treat intracranial metastasis were retrospectively reviewed. The clinical presentation of DM-only was compared with that of brain metastasis (BM)/leptomeningeal metastasis (LM).
RESULTS: Eight patients had DM and 25 patients had BM/LM. Median survival was 12 months in patients with DM and 7 months in those with BM/LM. Multivariate analysis found that only a Karnofsky performance status of ≥70 was significantly associated with improved OS. DM did not cause the death of any patient. Symptoms did not worsen in any DM patient.
CONCLUSION: WBRT can be considered for patients with DM alone for symptom improvement and preventing DM-related death.
PATIENTS AND METHODS: The medical records of thirty-three breast cancer patients who received WBRT to treat intracranial metastasis were retrospectively reviewed. The clinical presentation of DM-only was compared with that of brain metastasis (BM)/leptomeningeal metastasis (LM).
RESULTS: Eight patients had DM and 25 patients had BM/LM. Median survival was 12 months in patients with DM and 7 months in those with BM/LM. Multivariate analysis found that only a Karnofsky performance status of ≥70 was significantly associated with improved OS. DM did not cause the death of any patient. Symptoms did not worsen in any DM patient.
CONCLUSION: WBRT can be considered for patients with DM alone for symptom improvement and preventing DM-related death.