Indian journal of endocrinology and metabolism · 2017
Increased Levels of Serum Interleukin-17 in Patients with Hashimoto's Thyroiditis.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Esfahanian Fatemeh, Ghelich Roghayeh, Rashidian Hoda, Jadali Zohreh
Аннотация
BACKGROUND: CD4+ T-cells play important roles in the pathogenesis of Hashimoto's thyroiditis (HT). However, there is limited data about characteristics and function of the newly interleukin (IL)-17-producing T-helper cells in this common autoimmune thyroid disorder.
AIM: The purpose of this study was to assess the levels of T-helper 17-related cytokines in sera of patients with HT.
MATERIALS AND METHODS: Cytokine concentrations were measured in 48 patients with overt (n = 23) and subclinical hypothyroidism (25) and 35 healthy controls using enzyme-linked immunosorbent assay.
RESULTS: The serum levels of IL-17 were significantly higher in patients than controls (P = 0.001) while no differences were observed with regard to levels of IL-22 and IL-23 between patients and normal controls.
CONCLUSION: These results suggest that IL-17 could play some role in the pathogenesis of HT.
AIM: The purpose of this study was to assess the levels of T-helper 17-related cytokines in sera of patients with HT.
MATERIALS AND METHODS: Cytokine concentrations were measured in 48 patients with overt (n = 23) and subclinical hypothyroidism (25) and 35 healthy controls using enzyme-linked immunosorbent assay.
RESULTS: The serum levels of IL-17 were significantly higher in patients than controls (P = 0.001) while no differences were observed with regard to levels of IL-22 and IL-23 between patients and normal controls.
CONCLUSION: These results suggest that IL-17 could play some role in the pathogenesis of HT.