Invasive Klebsiella pneumoniae Causing Concurrent Liver and Pulmonary Abscesses: Successful Management With Prolonged Oral Amoxicillin-Clavulanate.

We report a rare case of a 59-year-old male patient with poorly controlled diabetes mellitus who presented with concurrent hepatic and pulmonary abscesses. Imaging revealed a large septated hepatic lesion and multiple bilateral pulmonary cavities. Cultures from blood and drained hepatic pus confirmed Klebsiella pneumoniae. Despite the lack of genomic testing, the clinical course was consistent with invasive Klebsiella pneumoniae syndrome (IKPS). The patient was treated successfully with prolonged intravenous and oral amoxicillin-clavulanate over six months, along with percutaneous drainage of the hepatic abscess. Follow-up imaging demonstrated near-complete resolution of both liver and lung lesions. This case highlights the importance of early source control and extended culture-guided antibiotic therapy in managing severe invasive Klebsiella infections in immunocompromised patients.