Italian pool of asbestos workers cohorts: asbestos related mortality by industrial sector and cumulative exposure.
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Magnani Corrado, Silvestri Stefano, Angelini Alessia, Ranucci Alessandra, Azzolina Danila, Cena Tiziana, Chellini Elisabetta, Merler Enzo, Pavone Venere, Miligi Lucia, Gorini Giuseppe, Bressan Vittoria, Girardi Paolo, Bauleo Lisa, Romeo Elisa, Luberto Ferdinando, Sala Orietta, Scarnato Corrado, Menegozzo Simona, Oddone Enrico, Tunesi Sara, Perticaroli Patrizia, Pettinari Aldo, Cuccaro Francesco, Mattioli Stefano, Baldassarre Antonio, Barone-Adesi Francesco, Musti Marina, Mirabelli Dario, Pirastu Roberta, Marinaccio Alessandro, Massari Stefania, Ferrante Daniela, Working Group Studio Multicentrico Italiano di Coorti di lavoratori dell’Amianto (SMICA), Working group Studio Multicentrico Italiano di Coorti di lavoratori dell’Amianto (SMICA):
Аннотация
METHODS: Pool of 43 Italian asbestos cohorts (asbestos cement, rolling stock, shipbuilding, glasswork, harbors, insulation and other industries). SMRs were computed by industrial sector for the 1970-2010 period, for the major causes, using reference rates by age, sex, region and calendar period.
RESULTS: The study included 51 801 subjects (5741 women): 55.9% alive, 42.6% died (cause known for 95%) and 1.5% lost to follow-up. Asbestos exposure was estimated at the plant and period levels. Asbestos related mortality was significantly increased. All industrial sectors showed increased mortality from pleural malignancies, and most also from peritoneal and lung cancer and asbestosis, with exposure related trend. Increased mortality was also observed for ovarian cancer and for bladder cancer.
DISCUSSION: The study confirmed the increased risk for cancer of the lung, ovary, pleura and peritoneum but not of the larynx and the digestive tract. A large increase in mortality from asbestosis was observed.