Shanghai kou qiang yi xue = Shanghai journal of stomatology · 2015
[The impact of smoking on human beta defensin 2,3 in gingival crevicular fluid and gingival tissue of patients with chronic periodontitis].
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Fan Yun, Ye Dong, Zhou Xin, Yu Fang-fang, Li Wei
Аннотация
PURPOSE: To study the impact of smoking on human beta defensin 2,3 expression in gingival crevicular fluid and gingival tissue of patients with chronic periodontitis.
METHODS: The study subjects were divided into chronic periodontitis with smoking and without smoking. Enzyme linked immunosorbent assay (ELISA) was used to detect the concentration of hBD2,3. RT-PCR was used to detect the mRNA expression of hBD2,3. SPSS17.0 software package was used for statistical analysis.
RESULTS: In GCF, the expression level of hBD2,3 in the smoking group was significantly lower than that in the non-smoking group. The mRNA expression level of hBD2,3 in the smoking group was weakened compared with that in the non-smoking group.
CONCLUSIONS: Smoking can change the expression of hBD2,3 in both GCF and gingivae, which indicates that smoking may have a negative effect on the immune defense system of the periodontal host.
METHODS: The study subjects were divided into chronic periodontitis with smoking and without smoking. Enzyme linked immunosorbent assay (ELISA) was used to detect the concentration of hBD2,3. RT-PCR was used to detect the mRNA expression of hBD2,3. SPSS17.0 software package was used for statistical analysis.
RESULTS: In GCF, the expression level of hBD2,3 in the smoking group was significantly lower than that in the non-smoking group. The mRNA expression level of hBD2,3 in the smoking group was weakened compared with that in the non-smoking group.
CONCLUSIONS: Smoking can change the expression of hBD2,3 in both GCF and gingivae, which indicates that smoking may have a negative effect on the immune defense system of the periodontal host.