Effect of Dexmedetomidine on Inflammatory Response in Aortic Dissection.

OBJECTIVE

To study the effect of dexmedetomidine (Dex) on perioperative inflammatory response in aortic dissection (AD) patients.

METHODS

From June 2020 to June 2022, 50 patients with Stanford type B AD underwent endovascular stent-graft exclusion (EVAR) at our hospital. They randomly were assigned to two groups (N = 25): the control group (C group) and the Dex group. Patients in the Dex group received 0.5ug/kg Dex intravenously 10 minutes before induction of anesthesia and 0.5µg/kg/h Dex during the intervention until 15 minutes before the end of surgery. In contrast, the C group received the same volume of normal saline at the same time points. The two groups were induced and maintained with the same anesthetic agents. Venous blood samples were taken 3 days before operation (T1), 1 day before operation (T2), 1 day after operation (T3) and 3 days after operation (T4) to detect levels of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and white blood cell count (WBC).

RESULTS

At T3 and T4, CRP and ESR in the Dex group were significantly improved compared with those in the C group.

CONCLUSION

Dexmedetomidine can reduce the inflammatory reaction of aortic dissection.