Journal of the neurological sciences · 2007
Reduplicative paramnesia in Morvan's syndrome.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Hudson Lynsee A, Rollins Yvonne D, Anderson C Alan, Johnston-Brooks Catharine, Tyler Kenneth L, Filley Christopher M
Аннотация
BACKGROUND: Morvan's syndrome is characterized by peripheral nervous system hyperexcitibility (myokymia and neuromyotonia), hyperhydrosis, sleep disorder, limb paresthesias, and encephalopathy. Voltage gated potassium channel antibodies (VGKC abs) are frequently present. Reduplicative paramnesia (RP) has not been reported with this disorder.
OBJECTIVE: To describe a patient with Morvan's syndrome presenting with RP.
DESIGN: Single case study.
PATIENT: A 64-year-old man with several years of myokymia and myoclonus with escalating parasomnia and confusion developed the delusion that a replica of his house and its contents existed 40 mi away.
RESULTS: Serum VGKC ab titer was elevated. Neuropsychological testing disclosed executive function and memory deficits. Electromyography demonstrated diffuse myokymia. Treatment with intravenous immunoglobulin and prednisone produced improvement of RP and myoclonus, but not myokymia.
CONCLUSION: RP may occur in patients with VGKC ab-associated Morvan's syndrome. Both RP and nervous system hyperexcitability may respond to immunotherapy including intravenous immunoglobulin and corticosteroids.
OBJECTIVE: To describe a patient with Morvan's syndrome presenting with RP.
DESIGN: Single case study.
PATIENT: A 64-year-old man with several years of myokymia and myoclonus with escalating parasomnia and confusion developed the delusion that a replica of his house and its contents existed 40 mi away.
RESULTS: Serum VGKC ab titer was elevated. Neuropsychological testing disclosed executive function and memory deficits. Electromyography demonstrated diffuse myokymia. Treatment with intravenous immunoglobulin and prednisone produced improvement of RP and myoclonus, but not myokymia.
CONCLUSION: RP may occur in patients with VGKC ab-associated Morvan's syndrome. Both RP and nervous system hyperexcitability may respond to immunotherapy including intravenous immunoglobulin and corticosteroids.
Предметные рубрики MeSH
Anti-Inflammatory AgentsAutoantibodiesCognition DisordersElectromyographyHumansImmunoglobulins, IntravenousImmunotherapyIsaacs SyndromeMaleMemory DisordersMiddle AgedMuscle, SkeletalMyokymiaNeuropsychological TestsPeripheral NervesPotassium Channels, Voltage-GatedPrednisoneSchizophrenia, ParanoidSyndromeTreatment Outcome