Meropenem/Vaborbactam in Pediatrics: 2 Cases of CRE Intraabdominal Infection.

Meropenem/vaborbactam is a combination antibiotic with a carbapenem and a carbapenemase inhibitor typically reserved for extensively drug-resistant bacterial infections, such as carbapenem-resistant Enterobacterales (CRE). Meropenem/vaborbactam is approved by the United States Food and Drug Administration for use in adults for complicated urinary tract infections, whereas data in the pediatric population are limited. This case series described the use of meropenem/vaborbactam in 2 pediatric patients, ages 11 and 15, with intraabdominal abscesses from CRE. Both patients had clinically improved after the initiation of meropenem/vaborbactam and reported no complications during their follow-up appointments after the completion of their antibiotic courses. These cases demonstrate the safe and effective use of meropenem/vaborbactam in these 2 pediatric patients. Although meropenem/vaborbactam successfully treated both patients' infections, additional data are needed in this population to determine the safety profile and optimal use for pediatric patients.