Leukemia & lymphoma · 2020
Validation and reference values of the EORTC QLQ-CML24 questionnaire to assess health-related quality of life in patients with chronic myeloid leukemia.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Efficace Fabio, Iurlo Alessandra, Patriarca Andrea, Stagno Fabio, Bee Ping-Chong, Ector Geneviève, Capodanno Isabella, Elena Chiara, Bonifacio Massimiliano, Blijlevens Nicole M A, Caocci Giovanni, Wan Chonghua, Abruzzese Elisabetta, Breccia Massimo, Cottone Francesco, Okumura Iris, Oerlemans Simone, Cascavilla Nicola, Albano Francesco, Kota Vamsi, Sztankay Monika, Miggiano Maria Cristina, Saussele Susanne, Di Renzo Nicola, Sorà Federica, Castagnetti Fausto, Baccarani Michele, Vignetti Marco, Rosti Gianantonio
Аннотация
Health-related quality of life (HRQOL) assessment is important to facilitate decisions in the current treatment landscape of chronic myeloid leukemia (CML). Therefore, the availability of a validated HRQOL questionnaire, specifically developed for CML patients treated with tyrosine kinase inhibitors (TKIs), may enhance quality of research in this area. We performed an international study including 782 CML patients to assess the validity of the EORTC QLQ-CML 24 questionnaire, and to generate HRQOL reference values to facilitate interpretation of results in future studies. Internal consistency, assessed with Cronbach's alpha coefficients, ranged from 0.66 to 0.83. In the confirmatory factor analysis, all standardized factor loadings exceeded the threshold of 0.40 (range 0.49-0.97), confirming the hypothesized scale structure. Reference values stratified by age and sex were also generated. Our findings support the use of the EORTC QLQ-CML 24, in conjunction with the EORTC QLQ-C30, as a valuable measure to assess HRQOL in CML patients.