Медицинская библиотека · Revista iberoamericana de micologia · 2021

Lack of relationship between genotype and virulence in Candida species.

Díaz-García Judith, Arendrup Maiken C, Cantón Rafael, García-Rodríguez Julio, de la Pedrosa Elia Gómez García, Parisi Gabriella, Pemán Javier, Posteraro Brunella, Sanguinetti Maurizio, Da Matta Daniel Archimedes, Colombo Arnaldo L, Muñoz Patricia, Sánchez-Carrillo Carlos, Guinea Jesús, Escribano Pilar

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Аннотация

BACKGROUND

The virulence of isolates among different Candida species causing candidemia may play a role in the prognosis of the patients. Furthermore, the potential relationship between genotype and virulence is still unclear and need to be further studied.

AIMS: We aim to assess the relationship between genotype and virulence in Candida species using a Galleria mellonella larvae infection model.

METHODS

One hundred and ninety-four isolates from 68 clusters (Candida albicans, 114/41; Candida parapsilosis, 74/24; Candida tropicalis, 6/3) were compared against the same number of each species singleton genotypes in terms of survival of G. mellonella larvae.

RESULTS

The median of survival and the IQR ranges of clusters and singleton were as follows: C. albicans (2 days, IQR 1.5-2 vs. 2 days, IQR 1-2.25), C. parapsilosis (2 days, IQR 1.5-2.6 vs. 2 days, IQR 2-3.3), and C. tropicalis (1 day, IQR 1-3.5 vs. 2 days, IQR 2-3.5; p<0.05). High intra-cluster variability in terms of median of survival was found regardless the species.

CONCLUSIONS

No relationship between genotype and virulence in Candida was observed with the G. mellonella model.

Для цитирования: Díaz-García Judith, Arendrup Maiken C, Cantón Rafael, García-Rodríguez Julio, de la Pedrosa Elia Gómez García, Parisi Gabriella, Pemán Javier, Posteraro Brunella, Sanguinetti Maurizio, Da Matta Daniel Archimedes, Colombo Arnaldo L, Muñoz Patricia, Sánchez-Carrillo Carlos, Guinea Jesús, Escribano Pilar. Lack of relationship between genotype and virulence in Candida species.. Revista iberoamericana de micologia. 2021. DOI: 10.1016/j.riam.2020.10.002.

Предметные рубрики MeSH

Candida Candida parapsilosis Candidemia Genotype Humans Virulence

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