Circulation · 2004
Functional recovery of stroke rats induced by granulocyte colony-stimulating factor-stimulated stem cells.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Shyu Woei-Cherng, Lin Shinn-Zong, Yang Hui-I, Tzeng Yi-Shiuan, Pang Cheng-Yoong, Yen Pao-Sheng, Li Hung
Аннотация
BACKGROUND: Stroke is a leading cause of death and disability worldwide; however, no effective treatment currently exists.
METHODS AND RESULTS: Rats receiving subcutaneous granulocyte colony-stimulating factor (G-CSF) showed less cerebral infarction, as evaluated by MRI, and improved motor performance after right middle cerebral artery ligation than vehicle-treated control rats. Subcutaneous administration of G-CSF enhanced the availability of circulating hematopoietic stem cells to the brain and their capacity for neurogenesis and angiogenesis in rats with cerebral ischemia.
CONCLUSIONS: G-CSF induced increases in bone marrow cell mobilization and targeting to the brain, reducing the volume of cerebral infarction and improving neural plasticity and vascularization.
METHODS AND RESULTS: Rats receiving subcutaneous granulocyte colony-stimulating factor (G-CSF) showed less cerebral infarction, as evaluated by MRI, and improved motor performance after right middle cerebral artery ligation than vehicle-treated control rats. Subcutaneous administration of G-CSF enhanced the availability of circulating hematopoietic stem cells to the brain and their capacity for neurogenesis and angiogenesis in rats with cerebral ischemia.
CONCLUSIONS: G-CSF induced increases in bone marrow cell mobilization and targeting to the brain, reducing the volume of cerebral infarction and improving neural plasticity and vascularization.
Предметные рубрики MeSH
AnimalsBiomarkersBone MarrowBrain ChemistryCell DifferentiationCell DivisionCell LineageDNA ReplicationDrug Evaluation, PreclinicalGranulocyte Colony-Stimulating FactorHead MovementsHematopoietic Stem Cell MobilizationHematopoietic Stem CellsInfarction, Middle Cerebral ArteryInjections, SubcutaneousLocomotionMaleNeovascularization, PhysiologicNeuronal PlasticityRatsRats, Sprague-DawleyReceptors, CXCR4Recovery of FunctionUp-Regulation