Advances in Preclinical Research of Theranostic Radiopharmaceuticals in Nuclear Medicine.

Theranostics of nuclear medicine refers to the combination of radionuclide imaging and internal irradiation therapy, which is currently a research hotspot and an important direction for the future development of nuclear medicine. Radiopharmaceutical is a vital component of nuclear medicine and serves as one of the fundamental pillars of molecular imaging and precision medicine. At present, a variety of radiopharmaceuticals have been developed for various targets such as fibroblast activation protein (FAP), prostate-specific membrane antigen (PSMA), somatostatin receptor 2 (SSTR2), C-X-C motif chemokine receptor 4 (CXCR4), human epidermal growth factor-2 (HER2), and integrin αvβ3, and some of them have been successfully applied in clinical practice. The radiopharmaceutical with theranostic function plays an important role in the diagnosis, treatment, efficacy evaluation, and prognosis prediction of cancers and is the key to realize the personalized treatment of tumors. This Review summarizes the preclinical research progress of theranostic radiopharmaceuticals toward the above targets in the field of nuclear medicine and discusses the prospects and development directions of radiopharmaceuticals in the future.