Preoperative Albumin-bilirubin Score and Colon Inflammatory Index Predict the Prognosis in Colorectal Cancer Patients: A Retrospective Study.

OBJECTIVES

The albumin-bilirubin (ALBI) score and colon inflammatory index (CII) are new sensitive scoring systems for several cancers. However, their clinical significance in colorectal cancer remains unclear. This study investigated the significance of ALBI score and CII for prognosis after colorectal cancer surgery.

METHODS

The present study analyzed data from patients who underwent curative resection for colorectal cancer. We investigated the association between preoperative ALBI score, CII, and disease-free and overall survival following surgery. Univariate and multivariate analyses were conducted to identify independent risk factors for poor prognosis in patients with colorectal cancer.

RESULTS

A total of 234 patients were included in the present study. Kaplan-Meier analysis demonstrated that patients with higher ALBI scores and poor CII had significantly worse disease-free and overall survival. In multivariate analysis, ALBI score ≥ -2.45 (P = 0.002), CII poor (P < 0.001), and pathological N1-3 stage (P = 0.017) were independent predictors of disease-free survival. Similarly, ALBI score ≥ -2.45 (P < 0.001 ), CII poor (P = 0.003), and pathological N1-3 stage (P = 0.015) were independent predictors of overall survival.

CONCLUSIONS

ALBI score and CII were strong predictors of poor prognosis in patients who underwent curative resection for colorectal cancer, emphasizing their potential utility in clinical practice. Incorporating these markers into routine clinical practice may enhance individualized treatment strategies and postoperative surveillance.