Clinical aspects of gastrointestinal mucus.

In such a bird's eye view of a very complicated and complex literature it is inevitable that significant contributions, particularly from earlier investigators, will have been overlooked. We have tried, however, to provide a reasonable framework for the many presentations and discussions which will take place at this conference. As in the past, it is evident that much needs to be done to reconcile the excellent histochemical studies of gastrointestinal mucus in many diseases with the increasing knowledge of mucin structure and composition. This will only be achieved by extraction of highly pure mucin from diseased bowel. In this regard, post mortem material provides an opportunity for mucin researchers which is not available to workers in other fields because of relative freedom from decomposition. The wedding of mucin technology with immunology is also a major priority. Immunoassay techniques provide the answer to quick and accurate product identification in secretion studies. Specific monoclonal antibodies will provide the route to structural differentiation of antigens in complex mixtures. It is also evident that we must seek to develop a variety of controllable models for the study of functional parameters of mucus in physiological conditions, parasite rejection, neoplasia and inflammatory states. Promising initiatives have been touched upon in this review, but these must only be the beginning. One must conclude, however, by recognizing that advances in knowledge have been truly remarkable since the last conference in 1976. One senses that some of the keys which will one day unlock the gates of this "ill-defined" kingdom are already in hand, while the remainder are at least within reach.