[Impact of nutritional status, inflammation and cardiovascular disease on the mortality of 90 Chinese peritoneal dialysis patients].

OBJECTIVE

To investigate the impact of nutritional status, inflammation and cardiovascular disease on the mortality of 90 patients with continuous ambulatory peritoneal dialysis (CAPD).

METHODS

A cross-sectional study was performed in 90 clinically stable CAPD patients. Patients' nutritional status (by SGA), chronic inflammation (by CRP), cardiovascular disease (CVD) were evaluated. All patients were followed for 24 months.

RESULTS

Thirty-three of the 90 (36.67%) patients died during the follow-up, five patients transferred to hemodialysis and 3 patients received transplantation. The causes of death were CVD in 12, infection in 13 and other causes in 7. Seventeen patients who died were malnourished. Malnourished patients had significantly higher mortality than well nourished patients (P<0.05). Patients with high serum CRP had higher mortality (P<0.01). CVD patients had also significantly higher mortality (P<0.01). The patients with malnutrition-inflammation-CVD (MIA) syndrome had significantly lower survival rate as compared with those with one or two components of MIA (P<0.01).

CONCLUSION

During 2-year follow up, 45 percent of 90 CAPD patients left the program. The most common causes of death were CVD and infection. Half of the patients who died were malnourished. Inflammation, malnutrition and CVD may have aggravated each other, and contributed to the poor outcome of this patient population.