Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis · 2003
Nutritional state correlates with renal function at the start of dialysis.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Cooper Bruce A, Aslani Alireza, Ryan Murielle, Ibels Lloyd S, Pollock Carol A
Аннотация
OBJECTIVE: To determine the effect of renal function at the commencement of dialysis on nutritional state.
DESIGN: Retrospective cohort study.
SETTING: University tertiary referral hospital.
PATIENTS: Patients with end-stage renal disease commencing renal replacement therapy over 8.5 years.
MAIN OUTCOME MEASURES: Total body nitrogen assessment using in vivo neutron activation analysis, expressed as nitrogen index (NI = observed total body nitrogen/predicted total body nitrogen); serum albumin measurement and creatinine clearance estimation, using the Cockcroft-Gault equation, at the start of dialysis. "Early" start group = creatinine clearance > 10 mL/minute (n = 26). "Late" start group = creatinine clearance < or = 10 mL/min (n = 108).
RESULTS: Mean NI was significantly lower [95% confidence interval (CI) 6%-30%, p < 0.0001] in the late start group (NI = 88%) compared to the early start group (NI = 106%). The late start group also had a significantly lower (95% CI 0.06-0.47 g/dL, p = 0.02) mean serum albumin level (3.66 g/dL) compared to that of the early start group (3.93 g/dL). A positive independent correlation existed between renal function and total body nitrogen (r2 = 0.21, p < 0.0001). No other clinical or demographic variable at the start of dialysis was found to predict nutritional state.
CONCLUSIONS: Patients that start dialysis with low levels of renal function are likely to be significantly malnourished. Whether this translates into a survival advantage requires prospective study.
DESIGN: Retrospective cohort study.
SETTING: University tertiary referral hospital.
PATIENTS: Patients with end-stage renal disease commencing renal replacement therapy over 8.5 years.
MAIN OUTCOME MEASURES: Total body nitrogen assessment using in vivo neutron activation analysis, expressed as nitrogen index (NI = observed total body nitrogen/predicted total body nitrogen); serum albumin measurement and creatinine clearance estimation, using the Cockcroft-Gault equation, at the start of dialysis. "Early" start group = creatinine clearance > 10 mL/minute (n = 26). "Late" start group = creatinine clearance < or = 10 mL/min (n = 108).
RESULTS: Mean NI was significantly lower [95% confidence interval (CI) 6%-30%, p < 0.0001] in the late start group (NI = 88%) compared to the early start group (NI = 106%). The late start group also had a significantly lower (95% CI 0.06-0.47 g/dL, p = 0.02) mean serum albumin level (3.66 g/dL) compared to that of the early start group (3.93 g/dL). A positive independent correlation existed between renal function and total body nitrogen (r2 = 0.21, p < 0.0001). No other clinical or demographic variable at the start of dialysis was found to predict nutritional state.
CONCLUSIONS: Patients that start dialysis with low levels of renal function are likely to be significantly malnourished. Whether this translates into a survival advantage requires prospective study.