Distinct characteristics of asthma overlap phenotypes: Insights from the Turkish adult asthma registry.
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Kepil Ozdemir Secil, Gemicioglu Bilun, Yildiz Fusun, Hayme Serhat, Alpagat Gulistan, Bozkurt Nurgul, Bulut Ismet, Erdinc Munevver, Karakaya Gul, Keren Metin, Pacaci Cetin Gulden, Yilmaz Insu, Yorgancioglu Arzu, Aydin Omur, Gokmen Derya, Koycu Buhari Gozde, Celebi Sozener Zeynep, Beyaz Sengul, Orcen Cihan, Damadoglu Ebru, Yakut Tugce, Kalpaklioglu Ayse Fusun, Baccioglu Ayse, Yalim Sumeyra Alan, Koca Kalkan Ilkay, Uysal Mehmet Atilla, Ozgun Niksarlioglu Elif Yelda, Kalyoncu Ali Fuat, Erbay Muge, Nayci Sibel, Tepetam Fatma Merve, Gelincik Aslı, Dirol Hulya, Goksel Ozlem, Karaoglanoglu Selen, Oner Erkekol Ferda, Isik Sacide Rana, Yavuz Yasemin, Karadogan Dilek, Seker Ummuhan, Oguzulgen Ipek Kivilcim, Basyigit Ilknur, Argun Baris Serap, Yilmazel Ucar Elif, Erdogan Tuba, Polatli Mehmet, Ediger Dane, Gunaydin Fatma Esra, Turk Murat, Pur Leyla, Yegin Katran Zeynep, Sekibag Yonca, Aykac Enes Furkan, Mungan Dilsad, Gul Ozcan, Cengiz Ali, Akkurt Bulent, Ozden Seyma, Demir Semra, Unal Derya, Aslan Ayse Feyza, Can Ali, Gumusburun Reyhan, Bogatekin Gulhan, Akten Hatice Serpil, Inan Sinem, Ogus Aliye Candan, Kavas Murat, Polat Yulug Demet, Cakmak Mehmet Erdem, Kaya Saltuk Bugra, Ozgur Eylem Sercan, Uzun Oguz, Tas Gulen Sule, Pekbak Gulseren, Kizilirmak Deniz, Havlucu Yavuz, Donmez Halil, Arslan Bahar, Soyyigit Sadan, Yilmaz Kara Bilge, Pasaoglu Karakis Gulden, Dursun Adile Berna, Kendirlinan Resat, Ozturk Ayse Bilge, Sevinc Can, Omeroglu Simsek Gokcen, Abadoglu Oznur, Cerci Pamir, Yucel Taskin, Yorulmaz Irfan, Tezcaner Zahide Ciler, Cadalli Tatar Emel, Suslu Ahmet Emre, Ozer Serdar, Dursun Engin, Celik Gulfem Elif
Аннотация
METHODS: This cross-sectional registry study included 2053 adult patients (74.8% female) with asthma.
RESULTS: Overall, 39.3% (n = 697) had allergic-eosinophilic (AE), 26.0% (n = 461) had allergic-non-eosinophilic (ANE), 21.3% (n = 377) had non-allergic-eosinophilic (NAE), and 13.4% (n = 237) had non-allergic-non-eosinophilic (NANE) asthma. Severe asthma exacerbations and emergency department (ED) visits were more frequent in the AE (28.3%, 31.2%, respectively) and NAE groups (36.0%, 34.0%, respectively) than in the ANE (14.3%, 20.6%, respectively) and NANE groups (12.6%, 16.7%, respectively) (p < 0.001). FEV1 values were significantly lower in the AE group than in the ANE and NANE groups (p < 0.001, p = 0.048, respectively) and in the NAE group than in the ANE group (p < 0.001). Risk factors for poor asthma control included living in rural areas, asthma-related ED visits, FEV1 < 60% in the NAE; being overweight, chronic rhinosinusitis, oral corticosteroids use, age < 40 years in the NANE; FEV1 < 80% in the AE; and severe asthma exacerbations, ED visits for AE and ANE groups.
CONCLUSION: The considerable overlap between allergic and eosinophilic asthma phenotypes has clinical implications as increased rates of asthma exacerbations and healthcare utilization. The clinical heterogeneity among asthma phenotypes based on a single biomarker highlights the importance of multidimensional asthma phenotyping.