Progress in mitral and aortic regurgitation.

Over the past 15 years there has been rapid and dramatic change in the therapy for valvular heart disease. When mitral and aortic regurgitation are severe, they inevitably cause left ventricular damage, eventually resulting in death. However, when surgical correction of these lesions is timed appropriately, longevity can approach that of a normal population after surgery. As surgical techniques have improved, surgery is now indicated earlier in the course of these diseases. It is clear that some patients with mitral and aortic regurgitation require surgery even though they are entirely asymptomatic. However, it must be emphasized that mitral and aortic regurgitation are quite different from one another. These different lesions result in different loading conditions, different pathophysiologies, and have different means for surgical correction. All of these issues impact on the proper timing of surgery and are discussed.