Neurology · 2005
Concomitant loss of dynorphin, NARP, and orexin in narcolepsy.
СтатьяПоддержка NIH: внешняя программаПоддержка службы здравоохранения СШАНазвание и аннотация: Перевод пока не подготовлен
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Crocker A, España R A, Papadopoulou M, Saper C B, Faraco J, Sakurai T, Honda M, Mignot E, Scammell T E
Аннотация
BACKGROUND: Narcolepsy with cataplexy is associated with a loss of orexin/hypocretin. It is speculated that an autoimmune process kills the orexin-producing neurons, but these cells may survive yet fail to produce orexin.
OBJECTIVE: To examine whether other markers of the orexin neurons are lost in narcolepsy with cataplexy.
METHODS: We used immunohistochemistry and in situ hybridization to examine the expression of orexin, neuronal activity-regulated pentraxin (NARP), and prodynorphin in hypothalami from five control and two narcoleptic individuals.
RESULTS: In the control hypothalami, at least 80% of the orexin-producing neurons also contained prodynorphin mRNA and NARP. In the patients with narcolepsy, the number of cells producing these markers was reduced to about 5 to 10% of normal.
CONCLUSIONS: Narcolepsy with cataplexy is likely caused by a loss of the orexin-producing neurons. In addition, loss of dynorphin and neuronal activity-regulated pentraxin may contribute to the symptoms of narcolepsy.
OBJECTIVE: To examine whether other markers of the orexin neurons are lost in narcolepsy with cataplexy.
METHODS: We used immunohistochemistry and in situ hybridization to examine the expression of orexin, neuronal activity-regulated pentraxin (NARP), and prodynorphin in hypothalami from five control and two narcoleptic individuals.
RESULTS: In the control hypothalami, at least 80% of the orexin-producing neurons also contained prodynorphin mRNA and NARP. In the patients with narcolepsy, the number of cells producing these markers was reduced to about 5 to 10% of normal.
CONCLUSIONS: Narcolepsy with cataplexy is likely caused by a loss of the orexin-producing neurons. In addition, loss of dynorphin and neuronal activity-regulated pentraxin may contribute to the symptoms of narcolepsy.
Предметные рубрики MeSH
AgedAutoantibodiesAutoimmune Diseases of the Nervous SystemBrain MappingC-Reactive ProteinDynorphinsHumansHypothalamusImmunohistochemistryIntracellular Signaling Peptides and ProteinsMaleMiddle AgedNarcolepsyNerve DegenerationNerve Tissue ProteinsNeural PathwaysNeurodegenerative DiseasesNeuronsNeuropeptidesOrexinsRNA, MessengerPentraxins