International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026
Anti-IFN-γ autoantibodies and disseminated opportunistic infections in immunocompetent Indian adults.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Bandyopadhyay Rini, Manesh Abi, Kundu Debasree, George Mithun Mohan, V Nagaraj, Varghese George M
Аннотация
OBJECTIVES: Though anti-IFN-γ autoantibodies are associated with adult-onset immunodeficiency among Asians, they are not routinely tested. Despite rising reports of disseminated opportunistic infections in apparently immunocompetent individuals, the clinical course and prevalence of anti-IFN-γ autoantibodies remain poorly characterized. We evaluated the association between severe opportunistic infections and plasma anti-IFN-γ antibodies and IL-12 levels.
METHODS: This cross-sectional study evaluated levels of anti-IFN-γ autoantibodies and IL-12 in HIV negative, apparently immunocompetent patients with disseminated intracellular opportunistic infections (Group 1; n = 44) or persistent tuberculosis (Group 2; n = 41) against healthy controls (Group 3; n = 34).
RESULTS: Common infections in Group 1 were disseminated non-tuberculous mycobacterial infections (40.9%), cryptococcosis (36.4%), and disseminated histoplasmosis (13.6%). Median anti-IFN-γ autoantibody concentrations were significantly higher in Group 1 [66.02 ng/mL; IQR 52.19-85.86; p = 0.004] and Group 2 [65.46 ng/mL; IQR 52.31-86.03; p = 0.004] than in Group 3 [44.77 ng/mL; IQR 28.56-69.93]. When compared to controls, IL-12 levels were significantly elevated in Group 1 (p = 0.006). In Group 1, three patients had relapses (6.8%), and three patients died (6.8%).
CONCLUSIONS: Patients with disseminated intracellular opportunistic infections and those with persistent tuberculosis had significantly higher levels of anti- IFN-γ autoantibodies than healthy controls. IL-12 levels were significantly higher in patients with disseminated intracellular opportunistic infections than among healthy controls. There was no significant difference in IL-12 levels among patients with persistent tuberculosis and healthy controls.
METHODS: This cross-sectional study evaluated levels of anti-IFN-γ autoantibodies and IL-12 in HIV negative, apparently immunocompetent patients with disseminated intracellular opportunistic infections (Group 1; n = 44) or persistent tuberculosis (Group 2; n = 41) against healthy controls (Group 3; n = 34).
RESULTS: Common infections in Group 1 were disseminated non-tuberculous mycobacterial infections (40.9%), cryptococcosis (36.4%), and disseminated histoplasmosis (13.6%). Median anti-IFN-γ autoantibody concentrations were significantly higher in Group 1 [66.02 ng/mL; IQR 52.19-85.86; p = 0.004] and Group 2 [65.46 ng/mL; IQR 52.31-86.03; p = 0.004] than in Group 3 [44.77 ng/mL; IQR 28.56-69.93]. When compared to controls, IL-12 levels were significantly elevated in Group 1 (p = 0.006). In Group 1, three patients had relapses (6.8%), and three patients died (6.8%).
CONCLUSIONS: Patients with disseminated intracellular opportunistic infections and those with persistent tuberculosis had significantly higher levels of anti- IFN-γ autoantibodies than healthy controls. IL-12 levels were significantly higher in patients with disseminated intracellular opportunistic infections than among healthy controls. There was no significant difference in IL-12 levels among patients with persistent tuberculosis and healthy controls.