Медицинская библиотека · Alzheimer's & dementia : the journal of the Alzheimer's Association · 2018
Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease.
Mattsson Niklas, Groot Colin, Jansen Willemijn J, Landau Susan M, Villemagne Victor L, Engelborghs Sebastiaan, Mintun Mark M, Lleo Alberto, Molinuevo José Luis, Jagust William J, Frisoni Giovanni B, Ivanoiu Adrian, Chételat Gaël, Resende de Oliveira Catarina, Rodrigue Karen M, Kornhuber Johannes, Wallin Anders, Klimkowicz-Mrowiec Aleksandra, Kandimalla Ramesh, Popp Julius, Aalten Pauline P, Aarsland Dag, Alcolea Daniel, Almdahl Ina S, Baldeiras Inês, van Buchem Mark A, Cavedo Enrica, Chen Kewei, Cohen Ann D, Förster Stefan, Fortea Juan, Frederiksen Kristian S, Freund-Levi Yvonne, Gill Kiran Dip, Gkatzima Olymbia, Grimmer Timo, Hampel Harald, Herukka Sanna-Kaisa, Johannsen Peter, van Laere Koen, de Leon Mony J, Maier Wolfgang, Marcusson Jan, Meulenbroek Olga, Møllergård Hanne M, Morris John C, Mroczko Barbara, Nordlund Arto, Prabhakar Sudesh, Peters Oliver, Rami Lorena, Rodríguez-Rodríguez Eloy, Roe Catherine M, Rüther Eckart, Santana Isabel, Schröder Johannes, Seo Sang W, Soininen Hilkka, Spiru Luiza, Stomrud Erik, Struyfs Hanne, Teunissen Charlotte E, Verhey Frans R J, Vos Stephanie J B, van Waalwijk van Doorn Linda J C, Waldemar Gunhild, Wallin Åsa K, Wiltfang Jens, Vandenberghe Rik, Brooks David J, Fladby Tormod, Rowe Christopher C, Drzezga Alexander, Verbeek Marcel M, Sarazin Marie, Wolk David A, Fleisher Adam S, Klunk William E, Na Duk L, Sánchez-Juan Pascual, Lee Dong Young, Nordberg Agneta, Tsolaki Magda, Camus Vincent, Rinne Juha O, Fagan Anne M, Zetterberg Henrik, Blennow Kaj, Rabinovici Gil D, Hansson Oskar, van Berckel Bart N M, van der Flier Wiesje M, Scheltens Philip, Visser Pieter Jelle, Ossenkoppele Rik
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Аннотация
INTRODUCTION
Apolipoprotein E (APOE) ε4 is the major genetic risk factor for Alzheimer's disease (AD), but its prevalence is unclear because earlier studies did not require biomarker evidence of amyloid β (Aβ) pathology.
METHODS
We included 3451 Aβ+ subjects (853 AD-type dementia, 1810 mild cognitive impairment, and 788 cognitively normal). Generalized estimating equation models were used to assess APOE ε4 prevalence in relation to age, sex, education, and geographical location.
RESULTS
The APOE ε4 prevalence was 66% in AD-type dementia, 64% in mild cognitive impairment, and 51% in cognitively normal, and it decreased with advancing age in Aβ+ cognitively normal and Aβ+ mild cognitive impairment (P < .05) but not in Aβ+ AD dementia (P = .66). The prevalence was highest in Northern Europe but did not vary by sex or education.
DISCUSSION: The APOE ε4 prevalence in AD was higher than that in previous studies, which did not require presence of Aβ pathology. Furthermore, our results highlight disease heterogeneity related to age and geographical location.
Для цитирования: Mattsson Niklas, Groot Colin, Jansen Willemijn J, Landau Susan M, Villemagne Victor L, Engelborghs Sebastiaan, Mintun Mark M, Lleo Alberto, Molinuevo José Luis, Jagust William J, Frisoni Giovanni B, Ivanoiu Adrian, Chételat Gaël, Resende de Oliveira Catarina, Rodrigue Karen M, Kornhuber Johannes, Wallin Anders, Klimkowicz-Mrowiec Aleksandra, Kandimalla Ramesh, Popp Julius, Aalten Pauline P, Aarsland Dag, Alcolea Daniel, Almdahl Ina S, Baldeiras Inês, van Buchem Mark A, Cavedo Enrica, Chen Kewei, Cohen Ann D, Förster Stefan, Fortea Juan, Frederiksen Kristian S, Freund-Levi Yvonne, Gill Kiran Dip, Gkatzima Olymbia, Grimmer Timo, Hampel Harald, Herukka Sanna-Kaisa, Johannsen Peter, van Laere Koen, de Leon Mony J, Maier Wolfgang, Marcusson Jan, Meulenbroek Olga, Møllergård Hanne M, Morris John C, Mroczko Barbara, Nordlund Arto, Prabhakar Sudesh, Peters Oliver, Rami Lorena, Rodríguez-Rodríguez Eloy, Roe Catherine M, Rüther Eckart, Santana Isabel, Schröder Johannes, Seo Sang W, Soininen Hilkka, Spiru Luiza, Stomrud Erik, Struyfs Hanne, Teunissen Charlotte E, Verhey Frans R J, Vos Stephanie J B, van Waalwijk van Doorn Linda J C, Waldemar Gunhild, Wallin Åsa K, Wiltfang Jens, Vandenberghe Rik, Brooks David J, Fladby Tormod, Rowe Christopher C, Drzezga Alexander, Verbeek Marcel M, Sarazin Marie, Wolk David A, Fleisher Adam S, Klunk William E, Na Duk L, Sánchez-Juan Pascual, Lee Dong Young, Nordberg Agneta, Tsolaki Magda, Camus Vincent, Rinne Juha O, Fagan Anne M, Zetterberg Henrik, Blennow Kaj, Rabinovici Gil D, Hansson Oskar, van Berckel Bart N M, van der Flier Wiesje M, Scheltens Philip, Visser Pieter Jelle, Ossenkoppele Rik. Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease.. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2018. DOI: 10.1016/j.jalz.2018.02.009.
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