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DOI 10.1007/s13205-025-04546-5

Медицинская библиотека · 3 Biotech · 2025

Fufang Huangqi Jianpi Oral Liquid alleviates spleen deficiency diarrhea via modulation of the NF-κB/Nrf2 signaling pathway and apoptosis.

Huang Lina, Qiu Zhengying, Sun Ke, Yu Cong, Huang Qilin, Liu Chen, Pan Xiangyi, Li Sifan, Ge Shaoguang, Shi Xiongwei, Hu Fangdi, Xin Ruihua

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Аннотация

INTRODUCTION

Human childbirth remains a complex and risky process for both mothers and infants, even with modern advancements in medical care. This study investigated the prevalence of obstetric interventions, namely caesarean sections, episiotomies, and forceps deliveries, along with the role of maternal-foetal body size mismatch in influencing delivery outcomes.

METHODS

Utilising two datasets from similar archival sources in two Swiss cities (Basel and Lausanne) from the 1920s, we explored the relevance of a mismatch between the body size of the mother and the foetus as a risk factor for obstetrical interventions and the duration of the expulsion phase during delivery.

RESULTS

Over 91% of births (1290/1407 in Basel and 1062/1145 in Lausanne) featured the foetal head in a normal position (either the right or left occiput anterior position). Episiotomies were performed in 8-17% of cases (233/1407 in Basel and 98/1145 in Lausanne) and forceps deliveries in 1-5% (17/1407 in Basel and 54/1145 in Lausanne). Caesarean sections were rare (<1%, 19/1407 in Basel and 6/1145 in Lausanne). Key findings indicated that larger foetal head diameters and narrower pelvic measurements were linked to prolonged expulsion phases and an increased likelihood of intervention. Abnormal head positions and first-time births were also associated with obstetrical interventions. Additionally, rickets was documented in 2% of mothers (23/1145) in Lausanne, correlating with increased forceps use and caesarean section rates.

CONCLUSION

This research provides insights into obstetric practices and maternal health conditions over a century ago, emphasising the significant impact of maternal-foetal body size mismatches on childbirth complications in a historical context.

Для цитирования: Huang Lina, Qiu Zhengying, Sun Ke, Yu Cong, Huang Qilin, Liu Chen, Pan Xiangyi, Li Sifan, Ge Shaoguang, Shi Xiongwei, Hu Fangdi, Xin Ruihua. Fufang Huangqi Jianpi Oral Liquid alleviates spleen deficiency diarrhea via modulation of the NF-κB/Nrf2 signaling pathway and apoptosis.. 3 Biotech. 2025. DOI: 10.1007/s13205-025-04546-5.
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