Медицинская библиотека · eLife · 2023

SARS-CoV-2 uses CD4 to infect T helper lymphocytes.

Brunetti Natalia S, Davanzo Gustavo G, de Moraes Diogo, Ferrari Allan J R, Souza Gabriela F, Muraro Stéfanie Primon, Knittel Thiago L, Boldrini Vinicius O, Monteiro Lauar B, Virgílio-da-Silva João Victor, Profeta Gerson S, Wassano Natália S, Nunes Santos Luana, Carregari Victor C, Dias Artur H S, Veras Flavio P, Tavares Lucas A, Forato Julia, Castro Icaro M S, Silva-Costa Lícia C, Palma André C, Mansour Eli, Ulaf Raisa G, Bernardes Ana F, Nunes Thyago A, Ribeiro Luciana C, Agrela Marcus V, Moretti Maria Luiza, Buscaratti Lucas I, Crunfli Fernanda, Ludwig Raissa G, Gerhardt Jaqueline A, Munhoz-Alves Natália, Marques Ana Maria, Sesti-Costa Renata, Amorim Mariene R, Toledo-Teixeira Daniel A, Parise Pierina Lorencini, Martini Matheus Cavalheiro, Bispos-Dos-Santos Karina, Simeoni Camila L, Granja Fabiana, Silvestrini Virgínia C, de Oliveira Eduardo B, Faca Vitor M, Carvalho Murilo, Castelucci Bianca G, Pereira Alexandre B, Coimbra Laís D, Dias Marieli M G, Rodrigues Patricia B, Gomes Arilson Bernardo S P, Pereira Fabricio B, Santos Leonilda M B, Bloyet Louis-Marie, Stumpf Spencer, Pontelli Marjorie C, Whelan Sean, Sposito Andrei C, Carvalho Robson F, Vieira André S, Vinolo Marco A R, Damasio André, Velloso Licio, Figueira Ana Carolina M, da Silva Luis L P, Cunha Thiago Mattar, Nakaya Helder I, Marques-Souza Henrique, Marques Rafael E, Martins-de-Souza Daniel, Skaf Munir S, Proenca-Modena Jose Luiz, Moraes-Vieira Pedro M M, Mori Marcelo A, Farias Alessandro S

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Аннотация

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the agent of a major global outbreak of respiratory tract disease known as Coronavirus Disease 2019 (COVID-19). SARS-CoV-2 infects mainly lungs and may cause several immune-related complications, such as lymphocytopenia and cytokine storm, which are associated with the severity of the disease and predict mortality. The mechanism by which SARS-CoV-2 infection may result in immune system dysfunction is still not fully understood. Here, we show that SARS-CoV-2 infects human CD4+ T helper cells, but not CD8+ T cells, and is present in blood and bronchoalveolar lavage T helper cells of severe COVID-19 patients. We demonstrated that SARS-CoV-2 spike glycoprotein (S) directly binds to the CD4 molecule, which in turn mediates the entry of SARS- CoV-2 in T helper cells. This leads to impaired CD4 T cell function and may cause cell death. SARS-CoV-2-infected T helper cells express higher levels of IL-10, which is associated with viral persistence and disease severity. Thus, CD4-mediated SARS-CoV-2 infection of T helper cells may contribute to a poor immune response in COVID-19 patients.

Для цитирования: Brunetti Natalia S, Davanzo Gustavo G, de Moraes Diogo, Ferrari Allan J R, Souza Gabriela F, Muraro Stéfanie Primon, Knittel Thiago L, Boldrini Vinicius O, Monteiro Lauar B, Virgílio-da-Silva João Victor, Profeta Gerson S, Wassano Natália S, Nunes Santos Luana, Carregari Victor C, Dias Artur H S, Veras Flavio P, Tavares Lucas A, Forato Julia, Castro Icaro M S, Silva-Costa Lícia C, Palma André C, Mansour Eli, Ulaf Raisa G, Bernardes Ana F, Nunes Thyago A, Ribeiro Luciana C, Agrela Marcus V, Moretti Maria Luiza, Buscaratti Lucas I, Crunfli Fernanda, Ludwig Raissa G, Gerhardt Jaqueline A, Munhoz-Alves Natália, Marques Ana Maria, Sesti-Costa Renata, Amorim Mariene R, Toledo-Teixeira Daniel A, Parise Pierina Lorencini, Martini Matheus Cavalheiro, Bispos-Dos-Santos Karina, Simeoni Camila L, Granja Fabiana, Silvestrini Virgínia C, de Oliveira Eduardo B, Faca Vitor M, Carvalho Murilo, Castelucci Bianca G, Pereira Alexandre B, Coimbra Laís D, Dias Marieli M G, Rodrigues Patricia B, Gomes Arilson Bernardo S P, Pereira Fabricio B, Santos Leonilda M B, Bloyet Louis-Marie, Stumpf Spencer, Pontelli Marjorie C, Whelan Sean, Sposito Andrei C, Carvalho Robson F, Vieira André S, Vinolo Marco A R, Damasio André, Velloso Licio, Figueira Ana Carolina M, da Silva Luis L P, Cunha Thiago Mattar, Nakaya Helder I, Marques-Souza Henrique, Marques Rafael E, Martins-de-Souza Daniel, Skaf Munir S, Proenca-Modena Jose Luiz, Moraes-Vieira Pedro M M, Mori Marcelo A, Farias Alessandro S. SARS-CoV-2 uses CD4 to infect T helper lymphocytes.. eLife. 2023. DOI: 10.7554/elife.84790.

Предметные рубрики MeSH

Humans SARS-CoV-2 COVID-19 CD8-Positive T-Lymphocytes T-Lymphocytes, Helper-Inducer Lung

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