Predictive efficiency of serum fibrinogen and D-Dimer levels for left ventricular remodelling after acute myocardial infarction.

OBJECTIVE

We aimed to explore serum D-dimer plus fibrinogen (FIB) levels in acute myocardial infarction (AMI) for their efficiency in predicting subsequent left ventricular remodelling (LVRM).

METHODS

With the period between September 2021 and January 2023 selected, 112 AMI patients hospitalised for treatment were enrolled as the subjects that were allocated to either the non-LVRM group (n = 76) or the LVRM group (n = 36) based on the findings of echocardiography.

RESULTS

LVRM was found in 36 out of the 112 AMI patients, with an incidence rate of 32.14%, whereas the remaining 76 patients did not develop LVRM, accounting for 67.86%. The LVRM-related risk factors in AMI subjects included large infarction size, high D-dimer level, history of diabetes mellitus plus hypertension, infarction location (apex of left ventricle), and high FIB level (odds ratio > 1, p < 0.05). FIB and D-dimer levels had the areas under the plotted receiver operating characteristic curves for predicting LVRM in AMI patients of 0.764 and 0.875, respectively, showing high predictive values. FIB and D-dimer levels had a certain value in predicting LVRM in AMI patients within the threshold range of 0.04-0.95.

CONCLUSION

The D-dimer and FIB level measurement for AMI sufferers is conducive to the prediction of LVRM incidence.