Archives of neurology · 2010
The stripe of primary lateral sclerosis: focal primary motor cortex hypometabolism seen on fluorodeoxyglucose F18 positron emission tomography.
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Claassen Daniel O, Josephs Keith A, Peller Patrick J
Аннотация
BACKGROUND: Primary lateral sclerosis (PLS) is a progressive upper motor neuron neurodegenerative condition. The diagnosis is made using clinical history, objective neurological assessment, and exclusion of other neurodegenerative disorders.
OBJECTIVE: To evaluate the role of fluorodeoxyglucose F18 positron emission tomography and 3-dimensional stereotactic surface projection in the diagnosis of PLS.
DESIGN: Case series.
SETTING: Outpatient neurology clinic. Patients Three cases of probable PLS. Intervention Fluorodeoxyglucose F18 positron emission tomography in 3 patients with PLS.
RESULTS: Three patients (2 male and 1 female; mean age, 65 years) were identified with a clinical diagnosis of PLS. Fluorodeoxyglucose F18 positron emission tomography demonstrated varying degrees of primary motor cortex hypometabolism.
CONCLUSION: Fluorodeoxyglucose F18 positron emission tomography and 3-dimensional stereotactic surface projection provide a useful diagnostic method to support a clinical diagnosis of PLS.
OBJECTIVE: To evaluate the role of fluorodeoxyglucose F18 positron emission tomography and 3-dimensional stereotactic surface projection in the diagnosis of PLS.
DESIGN: Case series.
SETTING: Outpatient neurology clinic. Patients Three cases of probable PLS. Intervention Fluorodeoxyglucose F18 positron emission tomography in 3 patients with PLS.
RESULTS: Three patients (2 male and 1 female; mean age, 65 years) were identified with a clinical diagnosis of PLS. Fluorodeoxyglucose F18 positron emission tomography demonstrated varying degrees of primary motor cortex hypometabolism.
CONCLUSION: Fluorodeoxyglucose F18 positron emission tomography and 3-dimensional stereotactic surface projection provide a useful diagnostic method to support a clinical diagnosis of PLS.
Предметные рубрики MeSH
AgedBrain MappingDiagnosis, DifferentialDisease ProgressionEnergy MetabolismFemaleFluorodeoxyglucose F18Gait Disorders, NeurologicHumansImage Processing, Computer-AssistedMaleMiddle AgedMotor CortexMotor Neuron DiseaseParesisPositron-Emission TomographyPredictive Value of TestsPseudobulbar PalsyPyramidal TractsRetrospective StudiesSensitivity and Specificity