Evidence-based treatment of chronic immune-mediated neuropathies.

Immune-mediated neuropathies are treatable disorders that can result in considerable disability in some cases. Chronic immune-mediated neuropathies include chronic inflammatory demyelinating polyradiculoneuropathy, multifocal motor neuropathy and neuropathy associated with monoclonal gammopathy. In recent years, therapeutic strategies for these disorders have become clearer as a result of large, randomized controlled trials. However, the treatments used can have serious adverse effects and at least 30% of patients do not respond to conventional therapies. The aim of this paper is to review available data on evidence-based immunotherapy of chronic immune-mediated neuropathies and to summarize recent findings and results obtained with new innovative therapies, such as new immunosuppressants and monoclonal antibodies.